TGF-β SIGNAL TRANSDUCTION
نویسندگان
چکیده
منابع مشابه
Tgf-β Signal Transduction
The transforming growth factor β (TGF-β) family of growth factors control the development and homeostasis of most tissues in metazoan organisms. Work over the past few years has led to the elucidation of a TGF-β signal transduction network. This network involves receptor serine/threonine kinases at the cell surface and their substrates, the SMAD proteins, which move into the nucleus, where they...
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Transforming growth factor-β (TGF-β) signaling regulates diverse cellular processes, including cell proliferation, differentiation, apoptosis, cell plasticity, and migration. TGF-β signaling can be mediated by Smad proteins or other signaling proteins such as MAP kinases and Akt. TGF-β signaling is tightly regulated at different levels along the pathways to ensure its proper physiological funct...
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Schnaper, H. William, Tomoko Hayashida, Susan C. Hubchak, and Anne-Christine Poncelet. TGFsignal transduction and mesangial cell fibrogenesis. Am J Physiol Renal Physiol 284: F243–F252, 2003; 10.1152/ajprenal.00300.2002.—Transforming growth factor(TGF) is closely associated with progressive renal fibrosis. Significant progress has been accomplished in determining the cellular signaling pathways...
متن کاملRegulation of TGF-β signal transduction by mono- and deubiquitylation of Smads.
Polyubiquitylation leading to proteasomal degradation is a well-established mechanism for regulating TGF-β signal transduction components such as receptors and Smads. Recently, an equally important role was suggested for monoubiquitylation of both Smad4 and receptor-associated Smads that regulates their function without protein degradation. Monoubiquitylation of Smads was discovered following t...
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The expression of DNA damage-binding protein 2 (DDB2) has been linked to the prognosis of ovarian cancer and its underlying transcription regulatory function was proposed to contribute to the favorable treatment outcome. By applying gene microarray analysis, we discovered neural precursor cell expressed, developmentally downregulated 4-Like (NEDD4L) as a previously unidentified downstream gene ...
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ژورنال
عنوان ژورنال: Annual Review of Biochemistry
سال: 1998
ISSN: 0066-4154,1545-4509
DOI: 10.1146/annurev.biochem.67.1.753